Pagoclone

Pagoclone, also known as pagoclone, is an anxiolytic drug in the cyclopyrrolone family, often used in conjunction with well-known medications such as the sleep aid zopiclone. It belongs to a newer class of drugs known as non-benzodiazepine analgesics, which have a different chemical structure but similar effects to conventional benzodiazepines.

Die Synthese von Pagoclone umfasst die Reaktion von 2-Amino-7-chlor-1,8-naphthyridin mit Phthalsäureanhydrid, was zum entsprechenden Phthalimid führt. Die selektive Reduktion einer der Imidcarbonylgruppen führt zur Bildung des entsprechenden Alkohols.

Pagoclone is a small molecular compound with the chemical formula C23H22ClN3O2. The average molecular weight is 407.893 g/mol.

research applications in science

Anti-anxiety properties: Pagoclone acts as a partial agonist at the γ-aminobutyric acid (GABA) A/benzodiazepine (BDZ) receptor and exhibits anti-anxiety properties without the typical side effects of benzodiazepines such as sedation and tolerance.

Neuropsychological performance: Studies show that higher doses may have mild adverse effects on learning and memory, although these changes are not statistically significant and disappear after six days of use.

Developmental Disorders: An exploratory study showed that Pagoclone effectively reduced stuttering symptoms.

Pharmacological effects: Research suggests that its anxiolytic effects are mediated by its primary metabolite 5′-hydroxypagoclone.

Pagoclone represents a potential advance in the treatment of anxiety and panic disorders. Its development includes phases of clinical trials that underline its potential as an effective treatment option.

Erfahren Sie mehr über die angstlösende Wirkung von Pagoclone (C23H22ClN3O2) und seine Anwendung bei Angststörungen auf NarcoChems.com.

Learn more about Pagoclone.